Selected Scientific Publications

The following includes selected scientific publications regarding AuroLase® Therapy and other commercial applications of AuroShell® Particles (also known as nanoshells).

AuroLase Therapy for the PhotoThermal Ablation of Tumors

"Vascular-targeted photothermal therapy of an orthotopic murine glioma model."
Day, E.S., Zhang, L., Thompson, P.A., Zawaski, J.A., Kaffes, C.C., Gaber, M.W., Blaney, S.M., West, J.L.
Nanomedicine (Lond). 2012 August;7(8):1133-48.

"Selective nanoparticle-directed ablation of the canine prostate."
Schwartz, J.A., Price, R.E., Gill-Sharp, K.L., Khorchani, J., Goodwin, B.S., Payne, J.D.
Lasers Surg Med. 2011 March; 43:(3), 213-20. doi: 10.1002/lsm.21039

"Nanoshells for photothermal cancer therapy."
Morton, J.G., Day, E.S., Halas, N.J., West, J.L.
Methods Mol Biol. 2010; 624, 101-17

"Feasibility study of particle-assisted laser ablation of brain tumors in orthotopic canine model."
Schwartz, J.A., Shetty, A.M., Price, R.E., Stafford, R.J., Wang, J.C., Uthamanthil, R.K., Pham, K., McNichols, R.J., Coleman, C.L., Payne, J.D.
Cancer Res 2009 February; 69:(4), 1659-1667.

"Selective prostate cancer thermal ablation with laser activated gold nanoshells."
Stern, J. M., Stanfield, J., Kabbani, W., Hsieh, J.T., Cadeddu, J.A.
J Urol. 2008 February; 179:(2), 748-53. Epub 2007 December 20.

"Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles."
O'Neal, D.P., Hirsch, L.R., Halas, N.J., Payne, J.D., West, J.L.
Cancer Lett. 2004 June 25; 209(2), 171-6.

"Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance."
Hirsch, L.R., Stafford, R.J., Bankson, J.A., Sershen, S.R., Rivera, B., Price, R.E., Hazle, J.D., Halas, N.J., West, J.L.
Proc Natl Acad Sci U S A. 2003 November.

AuroLase Therapy as an Adjunct to Radiation Therapy or Imaging

"Tracking of multimodal therapeutic nanocomplexes targeting breast cancer in vivo."
Bardhan, R., Chen, W., Bartels, M., Perez-Torres, C., Botero, M.F., McAninch, R.W., Contreras, A., Schiff, R., Pautler, R.G., Halas, N.J., Joshi, A.
Nano Lett. 2010; 10(12), 4920-8.

"Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy."
Atkinson, R.L., Zhang, M., Diagaradjane, P., Peddibhotla, S., Contreras, A., Hilsenbeck, S.G., Woodward, W.A., Krishnan, S., Chang, J.C., Rosen, J.M.
Sci Transl Med. 2010 October 27; 2(55), 55ra79.

"Nanoparticle-mediated thermal therapy: evolving strategies for prostate cancer therapy."
Krishnan, S., Diagaradjane, P., Cho, S.H.
Int J Hyperthermia. 2010; 26(8), 775-89. Epub 2010 September 21.

"Near-infrared narrow-band imaging of gold/silica nanoshells in tumors."
Puvanakrishnan, P., Park, J., Diagaradjane, P., Schwartz, J.A., Coleman, C.L., Gill-Sharp, K.L., Sang, K.L., Payne, J.D., Krishnan, S., Tunnell, J.W.
J Biomed Opt. 2009 March-April; 14(2), 024044.

"Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy."
Diagaradjane P., Shetty A., Wang J.C., Elliott A.M., Schwartz J., Shentu S., Park H.C., Deorukhkar A., Stafford R.J., Cho S.H., Tunnell J.W., Hazle J.D., Krishnan S.
Nano Lett. 2008 May; 8(5), 1492-500. Epub 2008 April 16.

"Two-photon-induced photoluminescence imaging of tumors using near-infrared excited gold nanoshells."
Park J., Estrada A., Sharp K., Sang K., Schwartz J.A., Smith D.K., Coleman C., Payne J.D., Korgel B.A., Dunn A.K, Tunnell J.W.
Opt Express. 2008 February 4; 16(3), 1590-9.

"Optically tunable nanoparticle contrast agents for early cancer detection: model-based analysis of gold nanoshells."
Lin A.W., Lewinski, N.A., West, J.L., Halas, N.J., Drezek, R.A.
J Biomed Opt. 2005 November-December; 10(6), 064035.

Other Commercial Applications

"Photothermal therapy in a murine colon cancer model using near-infrared absorbing gold nanorods."
Goodrich, G.P., Bao, L., Gill-Sharp, K., Sang, K.L., Wang, J., Payne, J.D.
J Biomed Opt. 2010 January-February; 15(1), 018001.

"Laser eye protection in a contact lens using plasmon resonant nanoparticles."
Goodrich, G.P., Payne, J.D., Wang, J.C., Jackson, J.B.
Proceedings Volume 7163: Ophthalmic Technologies XIX.

"Temperature-sensitive hydrogels with SiO2–Au nanoshells for controlled drug delivery."
Bikram M., Gobin A.M.,Whitmire R.E., and West J.L. 
Journal of Controlled Release, Volume 123, Issue 3, 20 November 2007, 219-227.

Near infrared laser-tissue welding using nanoshells as an exogenous absorber"
Gobin, A.M., O'Neal, D.P., Watkins, D.M., Halas, N.J., Drezek, R.A., West, J.L.
Lasers Surg Med. 2005 August; 37(2), 123-9.